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Bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase: structure and function in bacterial NAD metabolism. (2008). Huang, N., Sorci, L., Zhang, X., Brautigam, C., Li, X., Raffaelli, N., Magni, M., Grishin, N.V., Osterman, A. L. and Zhang, H.  Structure, 16, 196-209. Link to the article.

Transcriptional regulation of NAD metabolism in bacteria. NrtR family of Nudix-related regulators. (2008). Rodionov, D., De Ingeniis, J., Mancini, C., Cimadamore, F., Zhang, H., Osterman, A. L. and Raffaelli, N. “Nuc. Acid Res. 36, 2047-2059. PDF Full Text.

Transcriptional regulation of NAD metabolism in bacteria. Genomic reconstruction of NiaR (YrxA) regulon. (2008). Rodionov, D., Li, X., Rodionova, I., Yang, C., Sorci, L., Dervyn, E., Martynowski, D., Zhang, H., Gelfand, M., and Osterman, A.  Nuc. Acid Res. 36, 2032-2046. PDF Full Text.

Structural basis for substrate binding and the catalytic mechanism of Type III Pantothenate kinase. (2008). Yang, K.; Strauss, E., Huerta, C. and Zhang, H. Biochemistry. 47, 1369-1380. PDF Full Text.

Identification and Characterization of an Archaeal Specific Riboflavin Kinase. (2008). Mashhadi, Z., Zhang, H., Xu, H. and White, R. H.  J. of Bacteriology. 190, 2615-2618. PDF Full Text.

Structure of a conserved hypothetical protein SA1388 from S. aureus reveals a capped hexameric toroid with two PII domain lids and a dinuclear metal center.  (2006). Saikatendu KS, Zhang X, Kinch L, Leybourne M, N.V. Grishin, and H. Zhang.  BMC Struct Biol. 6:27. PDF full Text.

Transition metal-catalyzed nonoxidative decarboxylation reactions. (2006). Liu, A. and Zhang, H.  (New Concept article). Biochemistry,  45, 10407-10411. PDF Full Text

Crystal Structure of a-Amino-b-Carboxymuconate-e-Semialdehyde Decarboxylase: Insight into the Active Site and Catalytic Mechanism of a Novel Decarboxylation Reaction. (2006). Martynowski, D., Eyobo, Y., Li, T., Yang, K., Liu, A. and Zhang, H.  Biochemistry. 45, 10412-10421. PDF Full Text

Crystal Structure of a Type III Pantothenate Kinase: Insight into the Mechanism of an Essential CoA Biosynthetic Enzyme Universally Distributed in Bacteria. (2006). Yang, K., Eyobo, Y., Brand, L. A., Martynowski, D., Tomchick, D., Strauss E. and Zhang, H.   J. Bacteriology 188, 5532-5540.  PDF Full Text

a-Amino-b-carboxymuconic-e-semialdehyde Decarboxylase (ACMSD) Is a New Member of the Amidohydrolase Superfamily. (2006). Li, T., Iwaki, H., Fu, R., Hasegawa, Y., Zhang, H., and Liu, A.  Biochemistry 30, 6628-6634. PDF Full Text

A comprehensive update of the sequence and structure classification of kinases. (2005). Cheek, S., Ginalski, K., Zhang, H. and Grishin, N.V. BMC Struct Biol. 5:6. PDF Full Text

Structural Analysis of Pseudomonas 1-Aminocyclopropane-1-carboxylate Deaminase Complexes: Insight into the Mechanism of a Unique Pyridoxal-5'-phosphate Dependent Cyclopropane Ring-Opening Reaction. (2004). Karthikeyan, S., Zhou, Q., Zhao, Z., Kao, C.-l., Tao, Z., Robinson, H., H.-w. Liu and H. Zhang.  Biochemistry,  43, 13328-13339. PDF Full Text

Raptor protein contains a caspase-like domain. (2004). Ginalski, K., Zhang H., and Grishin, N. V.  Trends in Biomedical Sciences, 29, 522-524. PubMed link.

Structural Analysis of 1-Aminocyclopropane-1-Carboxylate Deaminase: Observation of an Aminyl Intermediate and Identification of Tyr 294 as the Active-Site Nucleophile. (2004)  Karthikeyan, S., Zhao, Z., Kao, C.-L., Zhou, Q., Tao, Z., Zhang, H.* and Liu, H.-w.* Agnew. Chem. Int. Ed. 43, 3425-3429. PDF Full Text.

The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity. (2004) Singh SK, Yang K, Subramanian K, Huynh T, Zhang X, Phillips MA, Zhang H.  J. Biol. Chem. 279, 13166-13173.  PDF Full Text.

Protein prenyltransferases. (2004). Zhang, H. In Handbook of Metalloproteins, Volume 3. p37-48. A. Messerschmidt, W. Bode and M.Cygler eds. John Wiley & Sons. PDF Full Text.

 Ligand-binding induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism. (2003). Karthikeyan, S., Zhou, Q., Osterman, A. L. and Zhang, H. Biochemistry,  42, 12532-12538.  PDF Full Text

Crystal structure of human riboflavin kinase reveals a b barrel fold and a novel active site arch. (2003).  Karthikeyan, S., Zhou, Q., Mseeh, F^., Grishin, N. V., Osterman, A. L. and Zhang, H.  Structure, 11, 265-273.  PDF Full Text. (Highlighted in Structure).

Binding platforms for Rab prenylation and recycling: Rab escort protein, RabGGT and RabGDI. (2003). Zhang, H.  Structure, 11, 237-239. PubMed Link.

Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis. (2003). Zhang, X., Kurnasov, O. V., Karthikeyan, S., Grishin, N.V., Osterman, A. L. and Zhang, H.   J. Biol. Chem., 278, 13503-11. PDF Full Text.

Structure of YibK from Haemophilus influenzae (HI0766): a methyltransferase with a cofactor bound at a site formed by a knot. (2003). Lim, K., Zhang, H., Toedt, J., Tempcyzk, A., Krajewski, W., Howard, A., Eisenstein, E., Herzberg, O.    Proteins Struc. Func. and Genetics, 51, 56-67.

Degradation Pathway of the Phosphonate Ciliatine: Crystal Structure of 2-Aminoethylphosphonate Transaminase. (2002). Chen, C. C., Zhang, H., Kim, A. D., Howard, A., Sheldrick, G. M., Mariano-Dunaway, D., Herzberg, O.  Biochemistry 41,13162-13169.

Crystal structure of Haemophilus influenzae NadR protein: a bifunctional enzyme endowed with NMN adenylyltransferase and ribosylnicotinamide kinase activities. (2002). Singh, S. K., Kurnasov, O. V.,  Chen, B., Robinson, H., Grishin, N. V., Osterman, A. L. and Zhang, H.^. J. Biol. Chem., 277, 33291-33299. PDF Full Text.

Sequence and Structure Classification of kinases. (2002). Cheek, S., Zhang, H. and Grishin, N. V.    J. Mol. Biol., 320 855-881. PDF Full Text.

Structure of human NMN/NaMN adenylyltransferase: basis for the dual substrate specificity and activation of oncolytic agent tiazofurin. (2002). Zhou, T., Kurnasov, O. V., Tomchick, D., Binns, D., Grishin, N. V., Marquez, V. E., Osterman, A. L. and Zhang, H.  J. Biol. Chem., 277, 13148-13154. PDF Full Text. 

Crystal structure of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD. (2002).  Zhang, H., Zhou, T., Kurnasov, O. V., Cheek, S., Grishin, N. V. and Osterman, A. L.  Structure, 10, 69-79. PDF Full Text. 

Structure and Mechanism of Homoserine Kinase: prototype for the GHMP kinase superfamily. (2000). Zhou, T., Daugherty, M., Grishin, N. V., Osterman, A. L. and Zhang, H.  Structure Fold. & Des. 8, 1247-1257.  PDF Full Text. PDB code 1FWK.

Crystal structure of YBAK protein from Haemophilus influenzae at 1.8Å resolution: 

structure-functional implications. (2000). Zhang, H., Huang, K., Li, Zhong, Banerjee, L., Fisher, K., 

Eisenstein, E., Grishin, N. V. and Herzberg, O.   Proteins Struc. Func. and Genetics. 40,

86-97. PDF Full Text.  PDB code 1DBU.

Crystal structure of Rab geranylgeranyl transferase at 2.0Å resolution. (2000). Zhang, H., Seabra, M. and Deisenhofer, J.  Structure Fold. & Des. 8, 241-251. PDF Full Text . PDB code 1DCE.