MAP Kinase and other Kinases

Low activity structure of ERK2

Phosphorylation site mutants of ERK2

Active Structure of ERK2

Structure of p38

Inhibitors of p38 bound to p38 and ERK2

c-Jun Kinase

A third MAP kinase, the c-Jun kinases are presently being tested for crystallization.

MEK's

The activatior of MAP kinases, MEK's are dual specificity kinases. MEK1 and MEK6 are presently being tested for crystallization.

Serpins

Structure of latent PAI-1

Latency transition mutants of PAI-1

Spontaneous conformational changes in PAI-1

Structure of Active Serpin K

Protein Therapeutics

Pyridoxal Phosphate Enzymes